ABSTRACT Cryptococcus neoformans is a pathogenic yeast that causes lethal cryptococcal meningitis in immunocompromised patients. One of the challenges in treating cryptococcosis is the development of resistance to azole antifungals. Previous studies linked azole resistance to elevated numbers of copies of critical resistance genes in aneuploid cells. However, how aneuploidy is formed in the presence of azole drugs remains unclear. This study showed that treatment with inhibitory concentrations of an azole drug, fluconazole (FLC), resulted in a significant population of cells with increased DNA content, through the following defects: inhibition of budding, premature mitosis, and inhibition of cytokinesis followed by replication in the mother...
<div><p><i>Cryptococcus gattii</i> is an emergent human pathogen. Fluconazole is commonly used for t...
Cryptococcus gattii is an emergent human pathogen. Fluconazole is commonly used for treatment of cry...
<div><p>Microbial pathogens have developed efficient strategies to compromise host immune responses....
Candida albicans, the most prevalent human fungal pathogen, is generally diploid. However, 50% of is...
Candida albicans, the most prevalent human fungal pathogen, is generally diploid. However, 50 % of i...
ABSTRACT Heteroresistance to fluconazole (FLC) in Cryptococcus is a transient adaptive resistance wh...
Cryptococcus neoformans is an opportunistic fungal pathogen that primarily infects the immunocomprom...
<p>Cryptococcus neoformans is a human fungal pathogen that can cause fatal meningitis in immunocompr...
Cryptococcus neoformans is a human fungal pathogen that can cause fatal meningitis in immunocompromi...
Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromi...
Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromi...
<p>Cryptococcus neoformans is a human fungal pathogen that can cause fatal meningitis in immunocompr...
Organismal ploidy and environmental stress impact the rates and types of mutational events. The oppo...
<div><p>Heteroresistance in <em>Cryptococcus neoformans</em> is an intrinsic adaptive resistance to ...
Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with flu...
<div><p><i>Cryptococcus gattii</i> is an emergent human pathogen. Fluconazole is commonly used for t...
Cryptococcus gattii is an emergent human pathogen. Fluconazole is commonly used for treatment of cry...
<div><p>Microbial pathogens have developed efficient strategies to compromise host immune responses....
Candida albicans, the most prevalent human fungal pathogen, is generally diploid. However, 50% of is...
Candida albicans, the most prevalent human fungal pathogen, is generally diploid. However, 50 % of i...
ABSTRACT Heteroresistance to fluconazole (FLC) in Cryptococcus is a transient adaptive resistance wh...
Cryptococcus neoformans is an opportunistic fungal pathogen that primarily infects the immunocomprom...
<p>Cryptococcus neoformans is a human fungal pathogen that can cause fatal meningitis in immunocompr...
Cryptococcus neoformans is a human fungal pathogen that can cause fatal meningitis in immunocompromi...
Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromi...
Pathogenic basidiomycetous yeast, Cryptococcus neoformans, causes fatal meningitis in immunocompromi...
<p>Cryptococcus neoformans is a human fungal pathogen that can cause fatal meningitis in immunocompr...
Organismal ploidy and environmental stress impact the rates and types of mutational events. The oppo...
<div><p>Heteroresistance in <em>Cryptococcus neoformans</em> is an intrinsic adaptive resistance to ...
Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with flu...
<div><p><i>Cryptococcus gattii</i> is an emergent human pathogen. Fluconazole is commonly used for t...
Cryptococcus gattii is an emergent human pathogen. Fluconazole is commonly used for treatment of cry...
<div><p>Microbial pathogens have developed efficient strategies to compromise host immune responses....